1) | IL-16 is involved in cancer diseases and correlates with the progression. |
| The results indicate that there is an increase of Interleukin-16 in sera during tumour progression due to an alteration in the function of the immunocompetent cells. |
| (Published in 2001) |
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2) | The simultaneous measurement of IL-6, sIL-6R and sgp130 in sera of tumour patients |
| patients is an important factor and necessary in evaluating the biological effect |
| of IL-6 in malignant diseases. |
| (Published in 2001) |
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3) | The serum values of sgp130 in cancer patients are elevated in all tumour stages. |
| There are a correlation between the values of sgp130 and sIL-6R in all tumour stages. |
| (Published in 2001) |
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4) | There are a significant correlation between the serum values of sICAM-1 and |
| sgp130 in cancer patients with progression. |
| (Published in 2005) |
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5) | IL-6 downregulates the membrane expression of gp130 in three multiple myeloma |
| cell lines (OPM-2, RPMI-8226, U-266), although the proliferation of the myeloma |
| cells increases. |
| (Published in 2003) |
| (Published in 2006) |
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6) | There are a relationship between the cytostatic (inhibition of proliferation) and the |
| cytocidal (killing of cells) effects of substances in multiple myeloma cell lines: Firstly |
| the proliferation of tumour cells is inhibited and then afterwards these cells |
| die by apoptosis or necrosis. |
| (Published in 2006) |
| (Published in 2008) |
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7) | IL-6 has a more marked effect on the proliferation of multiple myeloma cells with |
| lower proliferation than on those with higher. |
| (Published in 2006) |
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8) | Viscum album extract (VAQuFrF) inhibits the proliferation of several human multiple myeloma cell lines. The profile of its antitumour effect is identical to that of Vincristine. |
| (Published in 2010) |
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9) | Interleukin-6 leads to a marked production of Interleukin-10 in several human multiple myeloma cell lines. Interleukin-10 is an Interleukin-6 related growth factor for multiple myeloma cells. |
| (Published in 2010) |